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The purpose of this paper is to provide theoretical basis and data support for researchers to choose appropriate international partners, provide a basis for Chinese research funding agencies, such as National Natural Science Foundation of China (NSFC) to formulate international research collaboration (IRC) strategies and policies and provide recommendations for the improvement of the internationalization level of China's basic scientific research.

Based on existing research, this study took output of “Major International (Regional) Joint Research Project” (MIJRP) funded by NSFC and participated by Chinese scholars in the meantime as the analysis object, proposed hypotheses and constructed the indicators of IRC and research output (RO). In addition, the mathematical statistics was used to compare the RO of China's IRC and nonIRC, and the statistical analysis model was used to measure the influence on RO of collaboration country's research capacity, research collaboration between China and US, scope of international research collaboration and reprint author country.

The RO of China's IRC is higher than that of nonIRC; research capacity of collaboration country has no inevitable effect on the RO of China's IRC; the RO of China's IRC participated by Americans is higher than that without American scholars; expanding the scope of China's IRC to some degree can increase RO; the RO of China's IRC led by foreigners is higher than that led by Chinese. In particular, China–US IRC and foreign scholars acting as the reprint author are two major factors for the RO of China's IRC.

Most of the traditional research on IRC are based on the co-author papers, and this study tried to analyze the characteristics and regularities on IRC from a new view of international collaboration projects, which can be a supplement to the traditional international collaboration research on co-author papers.